Protective effects of sodium copper chlorophyllin on chlorpyrifos-induced thyroid toxicity in adult female rats

Abstract

Objective: Chlorpyrifos (CP), a prevalent organophosphorus pesticide, is deposited in crops and poses a significant risk to human and animal health, particularly the thyroid. This paper investigated the preventive benefits of sodium copper chlorophyllin (SCC), an aqueous derivative of chlorophyll with antioxidant and anti-inflammatory properties, against CP-induced thyroid damage in rats.

Method:

Group 1 (Control), Group 2 (CP, 6.7mg/kg), Group 3 (SCC, 50 mg/kg), Group 4 (CP + SCC Low Dose, 6.7 mg/kg CP+ 50 mg/kg SCC), and Group 5 (CP + SCC High Dose, 6.7 mg/kg CP+ 100 mg/kg SCC) were randomly assigned to 30 adult rats. Oral, daily treatments lasted six weeks. After taking blood samples, thyroid hormone (T3, T4, TSH) and inflammation parameters (IL-10, TNF-2) were measured and thyroid tissues were histopathologically examined.

Results:

CP exposure lowered serum T3, T4, TSH, and cytokines via increasing IL-10 and decreasing TNF-alpha. SCC alone contributed little. SCC decreased CP's effects on hormones (T3, T4, and TSH) and inflammatory cytokines (IL-10, TNF-a) when used together. Histopathological results confirmed biochemical results.

Conclusion:

SCC protects the thyroid from CP aspiration due to its antioxidant and anti-inflammatory properties. More research is needed to prove its medical value.