Anti-craving Property of Chlorpromazine in Pentazocine addiction among sickle cell disease patients: A Case Series

Authors

  • Falade J Afe Babalola University Ado Ekiti
  • Osho PO Department of Heamatology, University of Medical Science.oNDO
  • Ajayi AA Department of Family Medicine, Osun State University Osogbo
  • Ogubgbemi AO Department of Family Medicine, Osun State University Osogbo
  • Dare RF Department of Mental Health, State Specialist Hospital Osogbo
  • Akinnuoye AA State Neuropsychiatric Hospital , Akure .Ondo State
  • Sajo S State Neuropsychiatric Hospital , Akure .Ondo State

DOI:

https://doi.org/10.38029/babcockuniv.med.j..v6i2.182

Keywords:

Sickle cell disease , Dependence, Pentazocine, Chlorpromazine, Case series

Abstract

Background: Opioids are useful in the management of vaso-occlusive crisis among Sickle Cell Disease patients; however, there is a need to search for drugs that can ameliorate the withdrawal symptoms without causing further dependence.

Case presentations: Three patients living with Sickle cell disease abusing Pentazocine were managed with Tab Chlorpromazine 100mg twice daily for three weeks and had a significant reduction in the level of craving and also experienced improved sleep. Chlorpromazine demonstrates a high affinity for dopamine (DA) receptors and acts as a receptor antagonist by inhibiting adenylate cyclase activity. 

Conclusion: Chlorpromazine was found to be useful in the management of cravings associated with Pentazocine addiction.

Author Biographies

Ajayi AA, Department of Family Medicine, Osun State University Osogbo

Lecturer 1

Ogubgbemi AO, Department of Family Medicine, Osun State University Osogbo

Lecturer 1

Akinnuoye AA, State Neuropsychiatric Hospital , Akure .Ondo State

Consultant Psychiatrist

Sajo S, State Neuropsychiatric Hospital , Akure .Ondo State

Consultant Psychiatrist

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Published

2023-12-31

How to Cite

FALADE, J., Osho, P. O., Ajayi, A. A., Ogungbemi, A. O., Dare, R. F., Akinnuoye, A. A., & Sajo, S. (2023). Anti-craving Property of Chlorpromazine in Pentazocine addiction among sickle cell disease patients: A Case Series. Babcock University Medical Journal, 6(2), 62–65. https://doi.org/10.38029/babcockuniv.med.j.v6i2.182

Issue

Section

Case Report