Acetate alleviates glucose dysregulation and atherogenic dyslipidaemia in experimentally induced PCOS

Authors

  • Areloegbe SE Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
  • Ugorji JN Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
  • Aturamu A Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
  • Oladele CA Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
  • Emereonye CF Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
  • Atuma CL Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
  • Akintayo CO Department of Internal Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
  • Omoruyi GO Department of Internal Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
  • Onyekweli SO Department of Radiation Oncology, Lagos State University Teaching Hospital, Idi-Araba, Lagos State, Nigeria
  • Adelekan OE Department of Obstetrics and Gynaecology, General Hospital Gbagada, Lagos State, Nigeria
  • Ajadi IO Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria
  • Ajadi MB Department of Chemical Pathology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria
  • Badejogbin OC Department of Physiology, School of Basic Medical Sciences, Babcock University, Ilishan, Ogun State, Nigeria
  • Ogunniyi OA Department of Neurology, Afe Babalola University Multisystem Hospital, Ado-Ekiti, Ekiti State, Nigeria
  • Ajayi K Department of Human Nutrition and Dietetics, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
  • Oyewole PA Department of Surgery, Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
  • Sanya OA Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
  • Olaniyi KS Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria

DOI:

https://doi.org/10.38029/babcockuniv.med.j..v8i1.719

Keywords:

Acetate, Atherogenic dyslipidaemia, Glucose dysregulation, Inflammation, PCOS

Abstract

Objective: Polycystic ovarian syndrome (PCOS) is a female reproductive disorder that originates from both endocrine and metabolic disruptions, affecting about 6-21% of women of reproductive age globally. Atherogenic dyslipidaemia refers to alterations in circulating lipid levels, which contribute to cardiovascular and renal complications in PCOS. Acetate, a short-chain fatty acid, has been reported to attenuate endocrine/metabolic complications as well as improve glucose homeostasis; hence, this study was designed to explore the effect of acetate on glucose dysregulation and dyslipidaemia in experimentally induced PCOS.

Methods: Female Wistar rats at eight weeks old were procured and assigned into four groups (n=6): Control (CTL), Letrozole (LET), Acetate (ACT), and LET+ACT. Letrozole (aromatase inhibitor; 1 mg/kg) administration for 3 weeks induced PCOS, and treatment with acetate was by co-administration for 3 weeks, during Letrozole administration.

Results: Rats with PCOS presented hyperandrogenism/hypoestrogenism as observed by elevated levels of testosterone, LH/FSH ratio, with a decrease in 17-β oestradiol and SHBG levels when compared with the negative control group. In addition, PCOS rats showed a significant increase in body and ovarian weight, as well as fasting insulin levels. Similarly, circulating levels of TC, LDL, TC/HDL ratio, IL-6, and LDH were elevated in PCOS rats, with a significant decrease (p<0.05) in HDL and nitric oxide in rats with PCOS when compared with the control group.

Conclusion: The present study revealed that acetate alleviates atherogenic dyslipidaemia and metabolic disturbance in the PCOS animal model.

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Published

2025-06-30

How to Cite

ARELOEGBE, S. E. J., Ugorji, J. N., Aturamu, A., Oladele, C. A., Emereonye, C., Atuma, C. L., Akintayo, C. O., Omoruyi, G. O., Onyekweli, S. O., Adelekan, O., Ajadi, I. O., Ajadi, M. B., Badejogbin, O. C., Ogunniyi, O. A., Ajayi, K., Oyewole, P. A., Sanya, O. A., & OLANIYI, K. S. (2025). Acetate alleviates glucose dysregulation and atherogenic dyslipidaemia in experimentally induced PCOS. Babcock University Medical Journal, 8(1), 356–365. https://doi.org/10.38029/babcockuniv.med.j.v8i1.719

Issue

Vol. 8 No. 1 (2025)

Section

Basic Medical Research

License

Copyright (c) 2025 Areloegbe SE, Ugorji JN, Aturamu A, Oladele CA, Emereonye CF, Atuma CL, Akintayo CO, Omoruyi GO, Onyekweli SO, Adelekan OE, Ajadi IO, Ajadi MB, Badejogbin OC, Ogunniyi OA, Ajayi K, Oyewole PA, Sanya OA, Olaniyi KS

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.