The Role of Nano Lutein Compound in Mitigating the Impact of Physiological Parameters in Albino Rats Subjected to Oxidative Stress: An Experimental Study

Abstract

Objective: This study investigated the use of the nano-lutein compound to reduce the negative effect of oxidative stress on some physiological parameters in male white rats.

Methods: Forty-eight male laboratory rats, 12–14 weeks old and 200–250 grams in weight, were used in this study, which was implemented in the animal house of the Department of Biology, College of Education, and the University of Al-Qadisiyah. The experimental animals (48 rats) were divided into six groups of eight rats per group. There were 5 experimental and one control group.

Results: The results of the current study showed a significant (P>0.05) increase in the level of urea, creatinine, and liver enzymes (ALT, AST, ALP), as well as oxidative stress indicators, and a significant (P>0.05) decrease in the level of antioxidants (glutathione, catalase, albumin) in the serum of the first treatment group (T1) under oxidative stress compared to the control and other treatments. In the fourth and fifth treatment groups, which were subjected to oxidative stress and normal or nano-lutein was administered, there was a clear improvement and significant (P>0.05) decrease in liver enzymes, kidney function indicators, and indicators of oxidative stress, and significant (P>0.05) increase in the level of serum antioxidants compared with treatment (T1).

Conclusion: White rats were administered nano-lutein, which exhibited significant efficacy in mitigating the detrimental impacts of oxidative stress on hepatic and renal function. The enhanced bioavailability and higher tissue penetration may elucidate its superior activity when compared with conventional lutein.