Therapeutic Potential of Ephedra alata Alcoholic Extract Against Lead Acetate-Induced Nephrotoxicity in Male Albino Rats: Biochemical, Histological, and Antioxidant Insights

Authors

  • Hassan AA Department of Biology, College of Education for Pure Sciences, University of Anbar, Ramadi, Anbar 31001, Iraq
  • Ali LH Department of Biology, College of Education for Pure Sciences, University of Anbar, Ramadi, Anbar 31001, Iraq

DOI:

https://doi.org/10.38029/babcockuniv.med.j..v8i1.828

Keywords:

Nephrotoxicity, Ephedra alata, Lead acetate, Antioxidants, Inflammation, Cytokines

Abstract

Objective: This study investigated the nephroprotective potential of Ephedra alata alcoholic extract against lead acetate-induced toxicity in rats.

Methods: Forty male albino rats were assigned to five groups: control, lead acetate only, E. alata only, therapeutic (lead + E. alata), and preventive (E. alata + lead). Kidney function, oxidative stress, cytokine levels, and tissue morphology were evaluated.

Results: Lead acetate significantly increased serum urea, creatinine, MDA, IL-1β, and TNF-α levels (p<0.05), while reducing GPx. Co-administration of E. alata reversed these alterations. Histologically, E. alata mitigated renal damage and preserved tissue structure.

Conclusion: Ephedra alata extract exhibits strong antioxidant and anti-inflammatory properties, effectively protecting against lead-induced nephrotoxicity in rats.

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Published

2025-06-30

How to Cite

Hassan, A. A., & Ali , L. (2025). Therapeutic Potential of Ephedra alata Alcoholic Extract Against Lead Acetate-Induced Nephrotoxicity in Male Albino Rats: Biochemical, Histological, and Antioxidant Insights. Babcock University Medical Journal, 8(1), 291–305. https://doi.org/10.38029/babcockuniv.med.j.v8i1.828

Issue

Vol. 8 No. 1 (2025)

Section

Research Article

License

Copyright (c) 2025 Hassan AA, Ali LH

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.